Key Information
Module Code | BMS5004 |
Module Title | Fundamental Principles of Pharmacology and Drug Development |
Credit value | 20 |
Module Leader | Dr. Lidia Maryniak |
Teaching Team | Dr. Martin Vreugdenhil Dr. Alexander Robinson |
Courses Enrolled | BSc (Hons) in Biomedical Sciences (US0625) |
Module Learning Outcomes (LO)
| 1. Perform experimental procedures in basic pharmacology, collate data, interpret results and write scientific reports. 2. Demonstrates an awareness of basic concepts of pharmacodynamics and an ability to apply these to therapeutic approaches. 3. Illustrate, for a variety of drugs, how pharmacokinetics determines their clinical action and dosage. 4. Outline and critically appraise the key stages in the drug development. |
Assessment Category, Type, Scope, Weighting, LO addressed. | Assessment 1: Coursework: Laboratory Report; 1500 words; (30% of module weight); (LO1). Assessment 2: Exam: Online Examination; 60mins + 10mins reading time; (70% of module weight); (LO 2,3 & 4). |
Assessment Date/s | Assessment 1. 16th November 2020 Assessment 2. 19th January 2021 |
Reassessment Date
| In Year Retrieval Assessment 1. TBC Assessment 2. TBC Reassessment (Summer Resits) Assessment 1. 6th July 2021 Assessment 2. 14th July 2021 |
Return of Work | You will receive feedback by the following dates (First attempts): Assessment 1. 14th December 2020 Assessment 2. 16th February 2021
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Extenuating Circumstances | For further details on the Extenuating Circumstances Procedure please see the iCity page below: |
Plagiarism
| You are reminded of the University’s Disciplinary Procedures that refer to plagiarism. A copy of the Disciplinary Procedure is available from iCity.
Except where the assessment of an assignment is group based, the final piece of work that is submitted must be your own work. Close similarity between assignments is likely to lead to an investigation for cheating. You must also ensure that you acknowledge all sources you have used. Submissions that are considered to be the result of collusion or plagiarism will be dealt with under the University’s Disciplinary Procedures, and the penalty may involve the loss of academic credits.
If you have any doubts about the extent to which you are allowed to collaborate with your colleagues, or the conventions for acknowledging the sources you have used, you should first of all consult module documentation and, if still unclear, your module leader. |
Turnitin | To obtain a Turnitin scan before submitting your work to your department please visit the University's ‘Turnitin at BCU’ Moodle site. Work that is submitted and scanned through this service is not stored on the main Turnitin system and this is NOT your submitted work. |
Conditions of Progression
| You must achieve an average module grade of 40% to successfully pass the module.
If you fail at first attempt, there will be the opportunity for an In-Year Retrieval (IYR), and then one final opportunity to pass the module during the resubmission period during Summer Resits as detailed above. |
Where to get help |
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Page BreakAssessment 1
Coursework: Laboratory Report. The word limit for this assignment is 1500 words (+/- 10%). The total word count must be stated at the end of your assignment. This assessment contribute to 30% of the module weight.
Submission Date: Monday 16th November by 12.00 (midday).
For your summative assignment 1, write a detailed and concise laboratory report based on the Virtual Smooth muscle pharmacology practical.
This assessment addresses the following Module Learning Outcomes:
LO1: Perform experimental procedures in basic pharmacology, collate data, interpret results and write scientific reports. To this end you will assessed on the following skills:
1. Keep a tissue preparation alive by providing it with sufficient nutrients, gasses and avoiding mechanical damage, and apply drugs affecting its function.
This will be demonstrated by a clear description of the methods, solutions, protocols, and equipment that allows stable recording of tonic and phasic contractions of smooth muscles and the effects of various drugs on them (20% of the mark).
2. Describe the spontaneous activity of the preparation and the effect of a drug qualitatively. Acquire, quantitatively analyse and illustrate the data reflecting the effect of the drugs
This will be demonstrated by a well-argumented choice of parameters and a qualitative and quantitative description of observations, illustrated by clear graphs and/or tables (35% of the mark).
3. Introduce aims, hypothesis, and objectives, interpret the effect of the drugs applied and evaluate the experiment
This will be demonstrated by an introduction providing background information that logically leads to testable hypotheses and clear objectives, sensible interpretations of the effects of the drugs applied and a critical evaluation of the experiment with suggestions for improvement.
Assessment Task
The aim of this virtual pharmacology laboratory session is to study the role of serotonin in gastric motility of the earthworm crop-gizzard preparation. This will be done by measuring the effect of serotonin on tonic and phasic contraction force and on the rate of phasic contractions of the longitudinal smooth muscles. We do this first by application of exogenous serotonin and then by increasing endogenous serotonin, using a selective serotonin reuptake inhibitor (SSRI). We will further test whether the effect of serotonin is dependent on the 5HT2 receptor, by using a 5HT7 receptor antagonist.
To prepare for the virtual practical you will be given a word document with ‘background information to the smooth muscle practical’, a PowerPoint with an ‘Introduction to the smooth muscle practical’ and suggestions of papers to read.
The practical can be experienced by viewing the narrated ‘Smooth muscle pharmacology virtual practical’ presentation. We will be using the following drugs:
The natural 5TH receptor ligand serotonin at a concentration of 3x10-7 mol/l
The SSRI fluvoxamine (5x10-5 M)
The 5HT7 receptor antagonist SB269970 hydrochloride (10-6 M)
The contraction force-time recordings are analysed in the ‘Smooth muscle pharmacology virtual practical’ presentation and the quantitative results are given I the Quantitative results smooth muscle pharmacology practical' Excel file.
You need to draw up on your knowledge of what you learnt from the BMS5004 module thus far. In your report you must include introduction, methods (preparation, equipment, solutions and experimental protocol), a description of the observations and a discussion of the results.
To start you of on writing the assignment you will be given detailed instructions of how to write a laboratory report in the 'Write up workshop smooth muscle pharmacology practical' presentation and a 'Suggestions for results smooth muscle pharmacology practical' document
The table below provides you with an idea of the weighting and the assessment criteria with hints of what to include for each section of your report.
Submission Details
Work must be submitted as
ELECTRONIC COPY via the Moodle assessment submission page.
Submit your work as a Word document.
The first page should be the Assignment Submission and Feedback sheet
Left-hand margin not less than 25mm, double-spaced between the lines.
Font should be 12 point Times Roman or Arial.
Graphs need to be produced using computer programmes (e.g. Microsoft Excel).
Formative Opportunities
Support workshop for the laboratory report in week 4 via Microsoft Teams.
Support workshop for the laboratory report in week 6 in the classroom/via Microsoft Teams.
Support workshop for the laboratory report in week 8 via Microsoft Teams.
References:
When referencing sources of information (books, journals) make sure you use the correct BCU Harvard Referencing System.
Credit will be given for appropriate use, range of sources and their quality. A copy of Harvard Guide is added on module site.
Avoid allegations of academic misconduct:
Don’t pass off someone else’s work as your own. This is plagiarism and is viewed very seriously by the University.
Acknowledge all sources that you have used in your assignment or project. For advice on referencing contact the Centre for Academic Success. Click for more information on iCity on referencing your work correctly.
Summarise information obtained from sources and provide a reference for it.
Use quotation marks if you are using the exact words of another person and provide a reference for it.
You are allowed to discuss the assignment with fellow students, but the written work should be your unique writing.
Don’t allow others to copy your work, or lend your work to other students.
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